https://doi.org/10.1140/epjs/s11734-024-01380-3
Regular Article
Effect of blood viscosity on the hemodynamic significance of coronary artery stenosis
1
Laboratory of Multiphase Physical and Biological Media Modeling, Ural Federal University, 620002, Ekaterinburg, Russia
2
Tyumen Cardiology Research Center, Tomsk National Research Medical Center, Russian Academy of Sciences, 625026, Tomsk, Russia
3
Sklifosovsky Research Institute of Emergency Care, 129090, Moscow, Russia
4
Department of Biomedical Physics and Engineering, Ural State Medical University, 620028, Ekaterinburg, Russia
Received:
11
September
2024
Accepted:
17
October
2024
Published online:
4
November
2024
This paper addresses the development of computational methods for the needs of interventional cardiology to evaluate coronary hemodynamics in patients with ischemic heart disease (IHD). In particular, the study focuses on the role of hemorheology in determining blood flow in stenotic coronary arteries. An algorithm to quantify the contribution of blood viscosity to vascular resistance (pressure drop -
) is proposed. The algorithm based on the idea of the contribution of three components to : anatomical features, stenosis-induced vortex formation, and normal viscous flow in the healthy segment. Data obtained from IHD patient’s angiography with catheterization were used for 3D artery reconstruction and boundary conditions set. The analysis was performed considering three plausible blood viscosities in the range of 3.5
5.5 mPa s. The Carreau model was used to account for the non-Newtonian blood properties. It was found that the contribution of blood viscosity to , not related to stenosis anatomy and vessel curvature, can reach up to 45%. Besides, the change of blood can significantly (1.5–2 times) increase the blood viscosity factor to the vessel resistance. The obtained results were interpreted in terms of the invasive fractional flow reserve (FFR) method, one of the most common clinical methods for determining the hemodynamic significance of stenosis. Changes in blood viscosity led to a correction of FFR within 2%. Obtained results are consistent with the results of known clinical observations. A correlation between patient blood viscosity and FFR accuracy is demonstrated.
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© The Author(s), under exclusive licence to EDP Sciences, Springer-Verlag GmbH Germany, part of Springer Nature 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
