https://doi.org/10.1140/epjs/s11734-025-01940-1
Regular Article
Dynamics of connector hubs in EEG functional networks with Parkinson’s disease
1
School of Aerospace Engineering, Xi’an Jiaotong University, 710049, Xi’an, China
2
State Key Laboratory for Strength and Vibration of Mechanical Structures, 710049, Xi’an, China
Received:
26
May
2025
Accepted:
7
September
2025
Published online:
8
October
2025
Parkinson’s disease (PD) induced the abnormalities of resting-state brain functional connectivity. The hubs play crucial roles in maintaining efficient information communication across brain networks, but their dynamical evolution under the PD remains unclear. Here, we defined the connector hubs that facilitate inter-network information processing and analyzed the temporal property of connector hubs in dynamic functional connectivity networks using the sourced EEG data of the PD and health control (HC) groups. First, the duration of connector hubs in PD patients significantly decreased under eye-open condition in the delta band, showing the diminished integration of slow oscillatory activity. Second, opening eyes led to increased integration in HCs, but this functional alternation response to eye condition was lost in PD patients. Then, stable connector hubs were identified in the somatomotor and frontoparietal networks, particularly in high-frequency bands. Finally, the theta band activities were significantly correlated with PD clinical score, and the declined motor ability in PD patients was related to decreased network integration. Our results deepen the understanding of hub reorganization in dynamic functional networks affected by PD and offer new perspectives on neural features of PD.
Supplementary Information The online version contains supplementary material available at https://doi.org/10.1140/epjs/s11734-025-01940-1.
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© The Author(s), under exclusive licence to EDP Sciences, Springer-Verlag GmbH Germany, part of Springer Nature 2025
Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
