https://doi.org/10.1140/epjs/s11734-025-02105-w
Regular Article
Evaluation of hydrodynamic properties of channels in brain parenchyma
1
Institute of Physics, Saratov State University, 83 Astrakhanskaya Street, 410012, Saratov, Russia
2
Department of Biology, Saratov State University, 83 Astrakhanskaya Street, 410012, Saratov, Russia
3
Institute of Biochemistry and Physiology of Plants and Microorganisms, Russian Academy of Sciences, 13 Prospekt Entuziastov, 410049, Saratov, Russia
a
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Received:
18
November
2025
Accepted:
8
December
2025
Published online:
16
December
2025
Abstract
The pathways by which beta-amyloid is transported from the brain parenchyma to the meningeal lymphatic vessels remain a subject of active debate. These pathways include the perivascular spaces of small parenchymal vessels, the interstitial space of the parenchyma, and—based on recent findings—small lymphatic vessels located adjacent to arteriolar perivascular spaces. Direct flow measurements in these structures are currently unavailable, and both the topology of the interstitial space and the cross-sectional geometry of the vessels are too complex for traditional analytical approaches. Here, we employ mathematical modeling to estimate the hydrodynamic resistance of cerebrospinal fluid flow within parenchymal channels. We introduce a method for post-processing previously acquired imaging datasets and provide a comparative evaluation of the hydrodynamic characteristics of parenchymal lymphatic vessels. To achieve this, we develop an approach for estimating hydrodynamic resistance in channels of arbitrary cross-sectional shape and present calculated results for channel fragments identified in the parenchyma of laboratory animals.
Supplementary Information The online version contains supplementary material available at https://doi.org/10.1140/epjs/s11734-025-02105-w.
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© The Author(s), under exclusive licence to EDP Sciences, Springer-Verlag GmbH Germany, part of Springer Nature 2025
Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
