https://doi.org/10.1140/epjs/s11734-026-02200-6
Regular Article
Psycholinguistic and graphological analysis as a method for assessing brain mechanisms of psychoemotional maladaptation in Andersen–Tawil syndrome
1
Doctor Expert Center for Medical and Forensic Sciences, 1 Spasonalykovskiy Per., 20, 119049, Moscow, Russia
2
Department of Clinical Physiology and Non-Drug Therapy, RUDN University, Miklukho-Maklaya Str., 6, 117198, Moscow, Russia
a
This email address is being protected from spambots. You need JavaScript enabled to view it.
Received:
25
December
2025
Accepted:
10
February
2026
Published online:
19
February
2026
Abstract
Clinical cases demonstrating the interplay of rare somatic diseases, their pharmacotherapy with neuropsychiatric side effects, and destructive psychological influence are of significant interest to specialists in forensic psychiatry, clinical psychology, and psycholinguistics, as well as to neurologists and therapists. This article presents a retrospective analysis of a clinical-expert case of a young male patient with genetically confirmed Andersen–Tawil syndrome and mixed anxiety–depressive disorder. The case is of particular value due to the identification through the analysis of handwritten texts (self-observation diary) of convergent signs indicating both a severe psycho-emotional state and systematic external influence of a manipulative nature. A comprehensive methodology was applied: analysis of medical documentation, pathopsychological examination, psycholinguistic discourse analysis, and graphological examination. The results of the interdisciplinary analysis reveal a complex interaction of factors. They indicate the formation of a specific psychopathological status in which symptoms of anxiety–depressive disorder, potentially exacerbated by the intake of high doses of acetazolamide, were combined with psycholinguistic markers of maladaptive coping strategies and identified signs of covert forms of external manipulative psychological influence. The presented approach demonstrates the utility of integrating clinical and psycholinguistic data for a holistic assessment of neurocognitive vulnerability.
Copyright comment Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
© The Author(s), under exclusive licence to EDP Sciences, Springer-Verlag GmbH Germany, part of Springer Nature 2026
Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
