https://doi.org/10.1140/epjs/s11734-026-02202-4
Regular Article
The effect of photobiomodulation therapy (635 nm) on Gap-43 expression in the CA3 subfield of the hippocampus in rats after septoplasty simulation
1
Medical Institute, Peoples’ Friendship, University of Russia (RUDN University), Miklukho-Maklaya Str., 117198, Moscow, Russia
2
Department of Biology, M.V. Lomonosov Moscow State University, Leninskie Gory, 1, 100190, Moscow, Russia
a
This email address is being protected from spambots. You need JavaScript enabled to view it.
Received:
30
December
2025
Accepted:
10
February
2026
Published online:
23
February
2026
Abstract
Septoplasty is one of the most common surgeries in otorhinolaryngology, but according to experimental studies, it is also the most stress-inducing procedure. The hippocampus is the primary target of stress-induced injury in the central nervous system. The hippocampus hosts important processes of neurogenesis and neuroplasticity, the formation of new neural connections. The primary mediator of neuroplasticity is the protein Gap-43 (Growth-Associated Protein 43), which can be used to assess the intensity of these processes in the hippocampus. Photobiomodulatory therapy (PBMT) is widely used in the early post-septoplasty period to reduce inflammation in the nasal cavity. In our study, we assessed Gap-43 expression in various hippocampal subfields after simulated septoplasty and determined the effect of PBMT on this process.
Copyright comment Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
© The Author(s), under exclusive licence to EDP Sciences, Springer-Verlag GmbH Germany, part of Springer Nature 2026
Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
