EPJ ST Special Issue: Non-equilibrium phase transitions in heterogeneous systems: biophysical aspects
- Published on 11 February 2020
This special issue is devoted to the problems of experimental and theoretical studies, as well as computer simulations of physical features of structural and phase transitions in various biological systems (blood, cell cultures, biogels, metastable bioliquids) involved in external macroscopically non-equilibrium processes (hydrodynamic flows; alternating magnetic and electrical fields, stochastic forcing, etc.). Special attention is focused on a detailed study of internal transformations on macroscopic physical properties and the behavior of the systems under study.
The special issue will be devoted to the following problems:
1. Phase condensations of ensembles of magnetic nanoparticles, suspended in blood and other biological liquids, induced by alternating and rotating magnetic fields as well as by circulating hydrodynamic flows of the ferrofluids, provoked by the rotating particles and bulk nuclei of the dense phases. The effect of the nuclei rotation, as well as the influence of hydrodynamic flows on the phase transitions, will be in focus of the papers. The main aim of these works is to develop the scientific background of new methods of addressed drug delivery in-vivo to the places of blood vessel thrombosis.
2. Dynamic remagnetization and heat production in ensembles of magnetic nanoparticles under the action of alternating magnetic fields; the effect of the particle’s aggregation on the macroscopic magnetic and heat phenomena. The aim of works of this direction is the progress in the scientific background of the method of magnetic hyperthermia for therapy of cancer and other tumor diseases.
3. Field-induced deformations and internal structural transformations in biological polymer gels under the action of an external magnetic field. The aim of these works is the development of the scientific background for the technology of magnetic gel scaffolds for engineering and regeneration of biological tissues.
4. Phase transformations in metastable biological liquids (supersaturated solutions) connected with the evolution of crystallite assemblages. Special attention will be paid to such processes and phenomena as the nucleation, dissolution, and growth of elliptical crystallites, the influence of hydrodynamic flows and external impacts (e.g., heat and mass fluxes) on the dynamics of particulate assemblages. Such phenomena as Ostwald ripening, agglomeration and disintegration of particles or aggregates in conditions of macroscopic hydrodynamic flow and taking into account specifics of biological liquids will be in focus of these works.
5. Theoretical modeling of a ferrofluid flow in channels of variable cross-sections and the fluid local dynamic response to an external magnetic field. The aim of these works is to create a theoretical basis for detecting the local blood flow velocity in blood vessels to determine the degree of the vessels narrowing with stenotic plaques.
6. Various peculiarities of pattern formation in metastable and nonequilibrium media, blood flows, ferrofluids, cell cultures, biogels, as well as in other biological media during the phase transformations represent the research direction covered by the present theme issue.
Papers dealing with powerful computational methods and complex simulations with high-performance computer clusters in the aforementioned research directions are welcome.
This issue will be of interest to a wide range of specialists in biomaterials, bioengineering, and biophysics. The issue can become a convenient forum for discussing trends and achievements, to find new solutions and to strengthen the research collaborations.
The Guest Editors invite authors to submit their original research and short reviews on the theme of this special issue. Manuscripts should be prepared using the latex template of EPJ ST, which can be downloaded here. Articles should be submitted to the Editorial Office of EPJ ST via the submission system at https://articlestatus.edpsciences.org/is/epjst/home.php by selecting "Non-equilibrium phase transitions in heterogeneous systems: biophysical aspects" as special issue not later than 17 June 2020.