Noise-induced structural transformations of oscillatory modes in calcium dynamics
Department of Theoretical and Mathematical Physics, Ural Federal University, Lenina, 51, 620000, Ekaterinburg, Russia
Accepted: 21 March 2023
Published online: 13 April 2023
The problem of analyzing the internal mechanisms of structural transformations of non-equilibrium regimes in multi-component biological systems with random fluctuations is considered. Based on the Li–Rinzel model, we study how parametric noise deforms calcium oscillations, which play a key role in cellular processes. The conditions under which random forcing generates or suppresses spiking calcium oscillations are discussed. Parametric analysis of such stochastic transformations of calcium relaxation self-oscillations is carried out using statistics extracted from direct modeling and a new theoretical approach based on the method of confidence domains.
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