https://doi.org/10.1140/epjs/s11734-024-01400-2
Regular Article
Dose dependency of subchronic lead acetate exposure on biophysical characteristics of rats’ right atrium and ventricle
1
Institute of Immunology and Physiology, Ural Branch of Russian Academy of Sciences, 106 Pervomayskaya Street, 620049, Yekaterinburg, Russian Federation
2
Yekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers, 30 Popov Street, 620014, Yekaterinburg, Russian Federation
3
Laboratory of Stochastic Transport of Nanoparticles in Living Systems, Ural Federal University, 51 Lenin Avenue, 620000, Yekaterinburg, Russian Federation
4
Ural State Medical University, 2 Repin Street, 620028, Yekaterinburg, Russian Federation
5
Laboratory of Mathematical Modeling of Physical and Chemical Processes in Multiphase Media, Ural Federal University, Lenin ave., 51, 620000, Ekaterinburg, Russian Federation
6
Otto-Schott-Institut für Materialforschung, Friedrich-Schiller-Universität-Jena, 07743, Jena, Germany
h l.v.toropova@urfu.ru, liubov.toropova@uni-jena.de
Received:
14
September
2024
Accepted:
5
November
2024
Published online:
20
November
2024
The study investigated the dose-dependent effects of lead acetate on the atrial and ventricular myocardium, as well as on hematological parameters in young male rats under subchronic conditions. A decrease in systolic blood pressure, pulse pressure, and heart rate was observed. Changes in the electrocardiographic indicators manifested themselves as an increase in the length of the RR and QT intervals, as well as a shift in the contour. Data on the different effects of lead exposure on the electrical and mechanical activity of isolated strips of right atrial and ventricular myocardium are presented. It has been shown for the first time that the mechanisms of heterometric regulation of atrial myocardial contractility are more sensitive to lead intoxication than those of the ventricle. The decay time of the calcium transient in the atrial myocardium of rats with lead exposure is slower than in the control group, and it increases with the length of the myocardial strip.
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© The Author(s), under exclusive licence to EDP Sciences, Springer-Verlag GmbH Germany, part of Springer Nature 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
