Eur. Phys. J. Special Topics 153, 471-474 (2008)
https://doi.org/10.1140/epjst/e2008-00487-3

Characterization of reconstructed human skin using Photoacoustic Spectroscopy

¹ Instituto de Pesquisa e Desenvolvimento (IP&D), Universidade do Vale do Paraíba (UNIVAP), Av. Shishima Hifumi 2911, São José dos Campos, SP, 12244-000, Brazil
² State University of Campinas (UNICAMP), Medical Sciences School (FCM), Cidade Universitária Zeferino Vaz, Campinas, SP, 13083-970, Brazil
³ State University of Campinas (UNICAMP), Gleb Wataghin Physics Institute (IFGW), Cidade Universitária Zeferino Vaz, Campinas, SP, 13083-970, Brazil
⁴ Universidade Estadual do Norte Fluminense (UENF), Laboratório de Ciências Físicas, Campos dos Goytacazes, RJ, 28013-600, Brazil
⁵ Centro Brasileiro de Pesquisas Físicas (CBPF), R. Xavier Sigaud 150, Rio de Janeiro, RJ, 22290-180, Brazil

Corresponding author: barja@univap.br

Abstract

Recent progress in skin culture techniques has led to the development of systems in which the reconstructed human skin obtained exhibits morphologic characteristics similar to those observed in vivo. Reconstructed human skin may be the best substrate for pharmacological tests of topically applied drugs; besides, it can be employed in the treatment of burns wounds and chronic skin ulcers. However, this newly developed material must be validated by comparison with human skin, in order to show that reconstructed skin presents characteristics similar to those of human skin. This was accomplished in the present work, through photoacoustic spectroscopy (PAS) measurements. Results show similarity between reconstructed skin and ex-vivo human skin, validating possible therapeutic and cosmetic treatments to be developed using the reconstructed human skin analyzed in this work.