Eur. Phys. J. Special Topics 225, 767-771 (2016)
https://doi.org/10.1140/epjst/e2015-50323-x

Regular Article

Incorporation of tramadol drug into Li-fluorohectorite clay: A preliminary study of a medical nanofluid

¹ Institute of Pharmacy and Food (IFAL), University of Havana, Habana, Cuba
² Institute of Materials Science and Technology (IMRE), University of Havana, Habana, Cuba
³ Equipe Agrégats, Interface, et Materiaux pour l'Energie, Université Montpellier, Montpellier, France
⁴ Group of Complex Systems and Statistical Physics, Physics Faculty, University of Havana, Habana, Cuba
⁵ Norwegian University of Science and Technology (NTNU), Trondheim, Norway

^a e-mail: jon.fossum@ntnu.no
^b e-mail: aramis@imre.uh.cu

Received: 13 December 2015
Revised: 4 May 2016
Published online: 15 July 2016

Abstract

During the last years, clays have been increasingly explored as hosts for drugs. In the present paper, we have been able to host the non-steroidal anti-inflammatory drug, Tramadol, into the clay Li-fluorohectorite (Li-Fh). We preliminary evaluate its incorporation by means of UV spectroscopy and X ray diffraction. Our results indicate that the clay hosts the drug molecule in its interlayer space. We suggest a set of parameters to guarantee an efficient incorporation process. Future studies will concentrate on the release of the drug from the clay nanofluid.