Bifurcations underlying sigh and eupnea rhythmic transition in a pre-Bötzinger complex model
School of Mathematical Science, Henan Institute of Science and Technology, 453003, Xinxiang, China
2 School of Aerospace and Applied Mechanics, Tongji University, 200092, Shanghai, China
Accepted: 21 June 2022
Published online: 11 July 2022
Neuronal networks control motor output through multi-rhythmic electrical activities with different frequencies and amplitudes of different neurons. For example, the pre-Bötzinger complex related to respiratory function exhibits sigh (slow frequency and large amplitude) and eupnea (fast frequency and small amplitude) rhythms. In the present paper, rhythm transitions modulated by several physiological factors are simulated in a coupling model composed of sigh and eupnea compartments, and the roles of ionic currents and the underlying bifurcation mechanism of the rhythm transitions are acquired. The transition from sigh- and eupnea-rhythm to the eupnea rhythm induced by the blockage of calcium or hyperpolarization-activated channels is related to supercritical Hopf bifurcation of the sigh compartment, and to the sigh rhythm caused by the blockage of persistent sodium channel or change of extracellular potassium concentration is associated with subcritical Hopf/fold limit cycle bifurcation of the eupnea compartment. The parameter regions of ionic currents and dynamical mechanism of rhythm transitions in the pre-Bötzinger complex are helpful for the modulation to the respiratory rhythms.
© The Author(s), under exclusive licence to EDP Sciences, Springer-Verlag GmbH Germany, part of Springer Nature 2022