https://doi.org/10.1140/epjs/s11734-023-00885-7
Regular Article
Method for indirect radiofluorination with [18F]FDG by biorthogonal reaction
1
UMHAT “St. Marina”, Cl. in Nuclear Medicine, 1 Hristo Smirnenski Blvd., Varna, Bulgaria
2
Department of Analytical Chemistry, Faculty of Chemistry and Pharmacy, 1 James Boucher Str., Sofia, Bulgaria
Received:
23
August
2022
Accepted:
15
May
2023
Published online:
15
June
2023
The [18F]-fluorodeoxyglucose ([18F]FDG) is a universal PET—radiopharmaceutical routinely applauded (oncology, cardiology and neurology) and produced by medical cyclotrons (18O(p,n)18F) in many clinics of Nuclear Medicine. Current trend in medicine is to become more personalized and new types of therapeutic and diagnostic radiopharmaceuticals are applied involving pre-targeting strategy. Using existing facilities and equipment in clinics for specific modification of approved radiopharmaceutical as [18F]FDG will provide unique toolbox in hands of physicians and will forward personalization of therapy in Nuclear Medicine. In the present study investigation over conjugation between [18F]FDG and aminooxy functionalized tetrazine by chemoselective oxime bond formation was done. Method for direct labeling of tetrazine derivative (clickable with trans cyclooctene moieties) with [18F]FDG used standard clinical laboratory settings was developed. The synthesis was carried out in a weakly acidic condition—pH 4–4.3; at 70 °C and in the presence of p-methoxyaniline as a catalyst. The progress of the reactions was monitored by radio-TLC, HPLC and to conform final formulation IR-ATR spectroscopy was used.
The original online version of this article was revised: The captions of Fig. 6 and Fig. 7 had mistakes. The captions have now been corrected.
A correction to this article is available online at https://doi.org/10.1140/epjs/s11734-023-00908-3.
Copyright comment corrected publication 2023
Copyright comment Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
© The Author(s), under exclusive licence to EDP Sciences, Springer-Verlag GmbH Germany, part of Springer Nature 2023. corrected publication 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
