https://doi.org/10.1140/epjs/s11734-023-01083-1
Review
New insights into phototherapy of glioblastoma: the meningeal lymphatics and sleep
1
Institute of Biochemistry and Physiology of Plants and Microorganisms, Russian Academy of Sciences, Prospekt Entuziastov 13, 410049, Saratov, Russia
2
Department of Biology, Saratov State University, Astrakhanskaya 82, 410012, Saratov, Russia
3
Institute of Physics, Saratov State University, Astrakhanskaya Str. 83, 410012, Saratov, Russia
Received:
27
November
2023
Accepted:
22
December
2023
Published online:
25
January
2024
The meningeal lymphatics (MLVs) play an important role in immunity and maintaining homeostasis of the central nervous system. Sleep is a natural state when lymphatic drainage becomes maximally active and, along with the flow of fluids, toxins and metabolites are removed from the brain. A decrease in function of MLVs is a key mechanism in the development of glioblastoma (GBM), which leads to the accumulation of excess fluid in the brain and an increase in intracranial pressure. Recently, promising methods of transcranial photostimulation (tPBM) of MLVs have been developed. It is interesting to note that tPBM of MLVs during sleep vs. wakefulness stimulates lymphatic drainage of brain tissues much more effectively. It is logical to expect that tPBM of MLVs during sleep will significantly increase the effectiveness of the GBM therapy. This review highlights new trends in the treatment of GBM, including tPBM of MLVs during sleep as a promising strategy in suppression of tumor progression.
Alexander Shirokov, Egor Ilukov, Inna Blokhina, Andrey Terskov, Viktoria Adushkina and Daria Zlatogosrkaya have contributed equally to this work.
Copyright comment Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
© The Author(s), under exclusive licence to EDP Sciences, Springer-Verlag GmbH Germany, part of Springer Nature 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
