https://doi.org/10.1140/epjs/s11734-025-01529-8
Regular Article
Effects of potassium channel blockage on chimera-like states in the excitatory–inhibitory neuronal network
Department of Physics, Central China Normal University, 430079, Wuhan, China
Received:
23
August
2024
Accepted:
16
February
2025
Published online:
13
March
2025
The coexistence of different states is a key topic when studying the collective behavior of neuronal networks. In particular, the coexistence of spiking activity and resting states, a phenomenon known as chimera-like state. In this paper, we construct an excitatory–inhibitory neuronal network based on the Hodgkin–Huxley model and investigate the effect of potassium channel blockage on the chimera-like state of the neuronal network. The results show that different degrees of potassium channel blockage can regulate the electrical activity of neurons, resulting in the neuronal network in all-resting, chimera-like, and all-spiking states. Additionally, excitatory coupling strength promotes the firing activity and synchronization of neurons in the network, while a certain strength of inhibitory coupling suppresses the firing and synchronization of neurons. It is also found that under the influence of synaptic background noise, larger inhibitory coupling strengths can conversely promote the firing of neurons in the network. Finally, it is demonstrated that the chimera-like state of the network is robust to network topology. Findings in this paper are important for understanding the effects of channel blockage on the collective behavior of neuronal networks and will deepen our understanding of the complexity of brain function.
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Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
