https://doi.org/10.1140/epjs/s11734-025-01644-6
Regular Article
Analysis of risk factors for acute radiation toxicity in cervical cancer patients in FIGO IIIC1 and IIIC2 stages treated with definitive chemoradiation
1
Faculty of Medical Sciences, Department of Clinical Oncology, University of Kragujevac, Kragujevac, Serbia
2
Center for Radiation Oncology, University Clinical Center Kragujevac, Kragujevac, Serbia
3
Department of Medical Studies, Academy of Applied Preschool Teaching and Health Studies, Ćuprija, Serbia
a
makizivkovicmarija@gmail.com
Received:
7
July
2024
Accepted:
23
April
2025
Published online:
11
May
2025
The application of high-precision radiotherapy greatly contributed to reducing the intensity of toxicity, but the frequency did not decrease significantly. The primary aim was the analysis of risk factors for the acute radiation toxicity in cervical cancer patients treated with definitive chemoradiation. A cohort case–control study was conducted based on the analysis of potential risk factors for the onset of acute radiation toxicity in cervical cancer patients in FIGO IIIC1 and IIIC2 stages treated with definitive external beam radiotherapy and chemopotentiation, with simultaneous integrated or sequential boost doses, brachytherapy, from January 2020 to January 2024 in a tertiary care hospital. This study integrated 92 patients. Clinically significant manifestations either of radiation toxicity were recorded in 28.3%. Univariate analysis showed statistical significance for numbers of chemotherapy cycles, GTVn boost doses, rectal volume V50 and V30, as well as sigma V45 (p < 0.05). By multivariate binary logistic regression, the number of chemopotentiation cycles applied, the height of the GTVn boost doses, rectal V50 and V45 of the sigma were the most significant factors (p < 0.05). Acute radiation toxicity in patients with cervical cancer in the IIIC1 and IIIC2 stage treated with highly precise radiotherapy techniques is most closely related to the number of cycles of chemotherapy and the height of the boost dose delivered to the GTVn. In order to reduce the risk for radiation toxicity, patients must be adequately prepared for each radiotherapy fraction by respecting the diet and care regime.
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© The Author(s), under exclusive licence to EDP Sciences, Springer-Verlag GmbH Germany, part of Springer Nature 2025
Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
