https://doi.org/10.1140/epjs/s11734-026-02287-x
Regular Article
The effect of molar and premolar extraction on the body’s stress response and brain activity in its regulation using low-intensity photobiomodulatory therapy
RUDN University, Miklukho-Maklaya St. 6, 117198, Moscow, Russia
a
This email address is being protected from spambots. You need JavaScript enabled to view it.
Received:
26
December
2025
Accepted:
18
March
2026
Published online:
10
April
2026
Abstract
The brain’s role in post-extraction stress regulation is one of integrating the intense trigeminal nociceptive signals and engaging descending autonomic reflexes. Acute dental pain activates a broad pain matrix (S1/S2, insula, ACC, etc.) that overlaps with stress and cardiovascular control centers, leading to sympathetic activation. Interventions that reduce pain or anxiety appear to modulate this brain–heart axis, as reflected in more favorable HRV and hemodynamic profiles.
Copyright comment Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
© The Author(s), under exclusive licence to EDP Sciences, Springer-Verlag GmbH Germany, part of Springer Nature 2026
Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
