https://doi.org/10.1140/epjs/s11734-021-00367-8
Review
Neuroimaging with light field microscopy: a mini review of imaging systems
1
College of Energy and Power Engineering, Nanjing University of Aeronautics and Astronautics, 210016, Nanjing, China
2
Research Center for Intelligent Sensing Systems, Zhejiang Laboratory, 311100, Hangzhou, China
3
Key Laboratory of Novel Target and Drug Study for Neural Repair of Zhejiang Province, School of Medicine, Zhejiang University City College, 310015, Hangzhou, China
4
School of Computer and Computing Science, Zhejiang University City College, 310015, Hangzhou, China
5
School of Brain Science and Brain Medicine, Zhejiang University, 310058, Hangzhou, China
a
depeng.wang@nuaa.edu.cn
d
zhangdm@zhejianglab.edu.cn
Received:
7
October
2021
Accepted:
7
December
2021
Published online:
3
January
2022
Light-field microscopy is an emerging technique that allows fast-speed volumetric imaging of the sample at microscale resolution. In the past years, the parallel development of light-field microscopy and genetically encoded calcium sensors has enabled a variety of fast-speed and large-scale neuroimaging at high resolution and sensitivity. These neuroimaging techniques have greatly enhanced our understanding of the mechanism under brain function and expedited our steps of decoding brain patterns. This review provides an overview of different versions of light-field microscopy used in neural imaging, and also offers a historic development outline of genetically encoded calcium sensors. Following that, the review intensively discussed light-field imaging of zebrafish neural activity. In the last section, we summarized the review and also envisioned the future of volumetric neuroimaging.
© The Author(s), under exclusive licence to EDP Sciences, Springer-Verlag GmbH Germany, part of Springer Nature 2022
