https://doi.org/10.1140/epjs/s11734-025-01614-y
Regular Article
Spatiotemporal synaptic integration in dendrites of interneuron-specific 3 cells
1
School of Physical Science and Technology, Beijing University of Posts and Telecommunications, 100876, Beijing, China
2
Key Laboratory of Mathematics and Information Networks (Beijing University of Posts and Telecommunications), Ministry of Education, 100876, Beijing, China
Received:
31
January
2025
Accepted:
31
March
2025
Published online:
13
April
2025
Interneuron-specific interneurons play a critical role in disinhibiting pyramidal neurons in the hippocampus by inhibiting other interneurons. These neurons receive synaptic inputs with diverse spatiotemporal properties in vivo. However, the dendritic mechanisms underlying the integration of these excitatory inputs remain unclear. Using a biophysical compartmental model, we predict that IS3 interneuron dendrites integrate excitatory inputs supralinearly, with distinct mechanisms underlying the supralinear integration through different pathway inputs. By simulating asynchronous input, we find that distal dendrites receiving inputs from the TA pathway exhibit high gain and integrate inputs over a broader time window, which is influenced by the NMDA receptor ratio. Secondly, similar to inputs on a single dendrite, IS3 interneurons integrate inputs supralinearly when receiving inputs across multiple branches, which is attributed to the smaller dendritic diameter, resulting in a modest disparity in spatial response. Interestingly, a shunting effect exists under the two pathway inputs, which suggests that the individual pathway’s function may be more pronounced in this neuron. These findings provide insight into the coding scheme of IS3 interneurons in neuronal oscillations.
Supplementary Information The online version contains supplementary material available at https://doi.org/10.1140/epjs/s11734-025-01614-y.
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Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
