https://doi.org/10.1140/epjs/s11734-026-02210-4
Regular Article
Detection of the first changes in the dynamics of metabolic characteristics in the system of increasing consequences of traumatic brain injury
1
Institute of Physics, Saratov State University, 83 Astrakhanskaya Street, 410012, Saratov, Russia
2
Department of Biology, Saratov State University, 83 Astrakhanskaya Street, 410012, Saratov, Russia
a
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Received:
29
December
2025
Accepted:
16
February
2026
Published online:
1
March
2026
Abstract
This study investigates the influence of mild traumatic brain injury (mTBI) on metabolic and behavioral parameters, including motor activity, fluid consumption, overall oxygen consumption (VO2) and carbon dioxide (VCO2) excretion. The experiment used the weight-drop of injury in animals and method of indirect calorimetry. The main focus of this work is on an approach to data analysis that involves identifying the optimal time intervals during the day for analysis, as these reveal differences between the control group and the group with mild traumatic brain injury. In the concept of this approach, it was found that mice with mTBI showed a significant decrease in motor activity and gas exchange parameters compared to the healthy control group during the night period. Taken together, our approach reveals changes on short (2- to 4-h) time scales that are significantly sustained at 10 days post-injury. The study highlights the importance of a detailed assessment of metabolic parameters, which may aid in the diagnosis and treatment of disorders after TBI.
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© The Author(s), under exclusive licence to EDP Sciences, Springer-Verlag GmbH Germany, part of Springer Nature 2026
Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
