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Special Topics

EPJ E - How the fruit fly got its spots

EPJ E - How the fruit fly got its spots

The eye of the Drosophila (fruit fly) is characterized by a neat hexagonal patterns, a fascinating system to study pattern formation in biology. A recent paper published in EPJ E proposes a new mechanism to explain the emergence of this pattern.

Researchers at the University of Michigan, Ann Arbor examined a spatially discrete, three variable reaction-diffusion model inspired by the interactions that create a periodic pattern of gene expression in the Drosophila eye. This model creates a regular pattern behind a moving front, as observed in eye discs, through a novel “switch and template” mechanism. In order to better understand this mechanism, the authors performed a detailed study of the model’s behaviour in one dimension, using a combination of analytic methods and numerical searches of parameter space. They find that patterns are created robustly, provided that there is an appropriate separation of time scales and that self-activation is sufficiently strong. The model operates in a strongly nonlinear regime where the final pattern depends on the initial conditions as well as on parameter values. This study highlights the important role that cellularisation and cell-autonomous feedback can play in biological pattern formation.

To read the full paper "Switch and template pattern formation in a discrete reaction-diffusion system inspired by the Drosophila eye" by M.W. Pennington and D.K. Lubensky, Eur. Phys. J. E 33 (2010) click here.

Managing Editors
Sandrine Karpe and Vijala Kiruvanayagam (EDP Sciences) and Sabine Lehr (Springer-Verlag)
Dear Sabine,
For me it was a great pleasure to work with you, Christian and Isabelle. All questions have been resolved very fast. And amiability and competence of Isabelle are inestimable. Best regards,

Natasha Kirova, CNRS & University Paris Sud, Orsay, France
Editor EPJ Special Topics 222/5, 2013

ISSN: 1951-6355 (Print Edition)
ISSN: 1951-6401 (Electronic Edition)

© EDP Sciences and Springer-Verlag

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