EPJ Plus Focus Point Issue: Breakthrough Optics- and Complex Systems-based Technologies of Modulation of Drainage and Clearing Functions of the Brain

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Published on 13 March 2023

Guest Editors: Jürgen Kurths, Thomas Penzel, Valery Tuchin, Teemu Myllylä, Ruikang Wang, Oxana Semyachkina-Glushkovskaya

The treatment of brain diseases during sleep is a pioneering trend in modern medicine. This is due to new discoveries in the science of lymphatic "vessels-vacuums" that clean the brain during deep sleep. Today, sleep is considered as a novel biomarker and a promising therapeutic target for brain diseases associated with the drainage system injuries and the blood-brain barrier (BBB) leakage, including Alzheimer's and Parkinson's diseases, depression, brain trauma and intracranial hemorrhages. This issue presents multi-disciplinary approaches, including nonlinear signal processing analysis, maсhine learning technologies, modeling of the brain drainage system, optical methods, brave and innovative ideas and very promising experimental and clinical results focusing on the study of therapeutic and diagnostic properties of sleep as well as the development of novel strategies for the modulation of restorative sleep functions.

All articles are available here and are freely accessible until 13 May 2023. For further information, read the Editorial.